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Abstract #2907

Evaluating Reproducibility and Repeatability of Penalty Function Based Methods for Quantitative Intravoxel Incoherent Motion Analysis

Esha Baidya Kayal1, Kedar Khare1, Raju Sharma2, Sameer Bakhshi2, Devasenathipathy Kandasamy2, and Amit Mehndiratta1,2
1Indian Institute of Technology Delhi, Delhi, India, 2All India Institute of Medical Sciences Delhi, Delhi, India


Reproducibility and repeatability of penalty-based IVIM analysis methodologies BE+TV and BE+HPF have been evaluated using clinical dataset with osteosarcoma in comparison with existing IVIM analysis methods. IVIM datasets at three time-points during chemotherapy were analyzed and healthy muscle tissue was used as local control for IVIM analysis and evaluation of scan-rescan repeatability and reproducibility. Results showed, parametric maps estimated by BE+TV and BE+HPF methods were observed to have higher reproducibility and lower spatial inhomogeneity than the existing IVIM analysis methods and produced satisfactory inter-scan agreement in parameters estimation proving its repeatability in clinical scenario.

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