Abstract #2918

Mapping of weak current-induced magnetic fields in a 3D volume of the human brain at high resolution: 2D vs. Simultaneous multi slice

Cihan Göksu^1,2, Klaus Scheffler^2,3, Fróði Gregersen^1,4,5, Hasan Hüseyin Eroğlu^1,4, Rahel Heule^2,3, Hartwig R. Siebner^1,6,7, Lars G. Hanson^1,4, and Axel Thielscher^1,4

¹Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark, ²High-Field Magnetic Resonance Center, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany, ³Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany, ⁴Section for Magnetic Resonance, DTU Health Tech, Technical University of Denmark, Kgs Lyngby, Denmark, ⁵Sino-Danish Center for Education and Research, Aarhus, Denmark, ⁶Department of Neurology, Copenhagen University Hospital, Bispebjerg, Denmark, ⁷Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark

Synopsis

Exact knowledge of current distributions induced by transcranial electrical stimulation (TES) in the brain is important for effective clinical use of TES. MRCDI uses MRI to measure the TES-induced magnetic fields for estimating the underlying current flow distributions. The estimation methods can benefit from highly sensitive volume MRCDI measurements at a high spatial resolution. Here, we advanced our 2D spoiled gradient-echo-based MRCDI method for a sparse volume acquisition by using simultaneous-multi-slice (SMS) acquisition. Our SMS strategy demonstrated 25% improvement in noise floors against 2D. We test the performance of our methods by phantom and human in-vivo experiments using cable-loop currents.

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