Abstract #2919

Toward static-inhomogeneity-insensitive detection of neuro-electro-magnetic fields via compensated rotary saturation

Maximilian Gram^1,2, Petra Albertova^1,2, Verena Schirmer², Martin Blaimer³, Matthias Gamer⁴, Martin J. Herrmann⁵, Peter Michael Jakob², and Peter Nordbeck^1,6

¹Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, ²Experimental Physics 5, University of Würzburg, Würzburg, Germany, ³Magnetic Resonance and X-ray Imaging Department Fraunhofer IIS, Fraunhofer Institute for Integrated Circuits IIS, Würzburg, Germany, ⁴Department of Psychology, University of Würzburg, Würzburg, Germany, ⁵Center of Mental Health, Dept. of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Würzburg, Würzburg, Germany, ⁶Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany

Synopsis

Resonant absorption during spin-lock preparation can be used to measure tiny oscillating magnetic fields acting as direct evidence of electrical neuronal activity. Different spin-locking techniques were compared with respect to their sensitivity in magnetic field detection. As a specialty, the oscillating magnetic fields were generated by the built-in gradient system in an offcenter slice. The spin-lock time was identified as the crucial parameter for the performance of NEMO (neuro-electro-magnetic-oscillations) detection, since minima and maxima in the signal amplitude emerged in phantom and in vivo experiments. Affirmative, the experimental results show an excellent agreement with simulation results.

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