Abstract #2920

Gradient based emulation of neuro-electro-magnetic oscillations: A validation technique for MRI-based detection of Biomagnetism

Petra Albertova^1,2, Maximilian Gram^1,2, Verena Schirmer¹, Martin Blaimer³, Martin J. Herrmann⁴, Matthias Gamer⁵, Peter Nordbeck^2,6, and Peter Michael Jakob¹

¹Experimental Physics 5, University of Würzburg, Würzburg, Germany, ²Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, ³Magnetic Resonance and X-ray Imaging Department, Fraunhofer IIS, Fraunhofer Institute for Integrated Circuits IIS, Würzburg, Germany, ⁴Center of Mental Health, Dept. of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany, ⁵Department of Psychology, University of Würzburg, Würzburg, Germany, ⁶Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany

Synopsis

Spin-lock based absorption of magnetic oscillations offers potential for direct detection of electrical neuronal activity. We propose a novel versatile validation and calibration technique which paves the way for emulation and quantification of biomagnetic fields. Using ultra-weak gradient waveforms, the method mimics brain activity and thus projects artificial fields onto the tissue under investigation. The method applicable for sequence validation or signal calibration was tested in phantom and in vivo experiments with the built-in gradient system providing sinusoidal field modulations down to 1 nT. It proved to be reliable and reproducible and hence can potentially enable quantification of biomagnetic fields.

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