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Abstract #2920

Gradient based emulation of neuro-electro-magnetic oscillations: A validation technique for MRI-based detection of Biomagnetism

Petra Albertova1,2, Maximilian Gram1,2, Verena Schirmer1, Martin Blaimer3, Martin J. Herrmann4, Matthias Gamer5, Peter Nordbeck2,6, and Peter Michael Jakob1
1Experimental Physics 5, University of Würzburg, Würzburg, Germany, 2Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, 3Magnetic Resonance and X-ray Imaging Department, Fraunhofer IIS, Fraunhofer Institute for Integrated Circuits IIS, Würzburg, Germany, 4Center of Mental Health, Dept. of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany, 5Department of Psychology, University of Würzburg, Würzburg, Germany, 6Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany


Spin-lock based absorption of magnetic oscillations offers potential for direct detection of electrical neuronal activity. We propose a novel versatile validation and calibration technique which paves the way for emulation and quantification of biomagnetic fields. Using ultra-weak gradient waveforms, the method mimics brain activity and thus projects artificial fields onto the tissue under investigation. The method applicable for sequence validation or signal calibration was tested in phantom and in vivo experiments with the built-in gradient system providing sinusoidal field modulations down to 1 nT. It proved to be reliable and reproducible and hence can potentially enable quantification of biomagnetic fields.

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