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Abstract #2940

Assessment of age-related changes of oxygen extraction fraction in of normal adults using QSM and quantitative BOLD

Jieyu Wang1, Junghun Cho2, Chen Zhang3, Yi Wang2, and Bing Yu4
1the Fourth Affiliated Hospital of China Medical University, Shenyang, China, 2Weill Cornell Medicine, New York, NY, United States, 3MR Scientific Marketing, Siemens Healthineers, Beijing, China, 4Shengjing Hospital of China Medical University, Shenyang, China


With aging, the brain undergoes comprehensive changes in its function and physiology, including oxygen consumption metabolism. In this study of healthy aging from 24-69, oxygen extraction fraction (OEF) mapping was generated using QSM and quantitative BOLD (QSM+qBOLD, QQ) processing of challenge-free 3D multi-echo gradient echo (mGRE). OEF values were found to increase with age only in specific gray matter brain regions (mainly in SomMot and SalVentAttn functional networks) and to decrease with age only in specific white matter brain regions (mainly Callosum ,cingulate,superior frontal blade).

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