Abstract #2940

Assessment of age-related changes of oxygen extraction fraction in of normal adults using QSM and quantitative BOLD

Jieyu Wang¹, Junghun Cho², Chen Zhang³, Yi Wang², and Bing Yu⁴

¹the Fourth Affiliated Hospital of China Medical University, Shenyang, China, ²Weill Cornell Medicine, New York, NY, United States, ³MR Scientific Marketing, Siemens Healthineers, Beijing, China, ⁴Shengjing Hospital of China Medical University, Shenyang, China

Synopsis

With aging, the brain undergoes comprehensive changes in its function and physiology, including oxygen consumption metabolism. In this study of healthy aging from 24-69, oxygen extraction fraction (OEF) mapping was generated using QSM and quantitative BOLD (QSM+qBOLD, QQ) processing of challenge-free 3D multi-echo gradient echo (mGRE). OEF values were found to increase with age only in specific gray matter brain regions (mainly in SomMot and SalVentAttn functional networks) and to decrease with age only in specific white matter brain regions (mainly Callosum ,cingulate,superior frontal blade).

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