Abstract #2941

Post-Therapy cortical normalization for phonological processing in developmental dyslexia

Sunita Gudwani^1,2, Manju Mehta³, Rajesh Sagar⁴, Madhuri Behari^5,6, Vaishna Narang⁷, Sadanad Sadanad Dwivedi⁸, N.R. Jagannathan², and S.Senthil Kumaran⁹

¹Dept. of NeuroRehab, speech therapy and audiology, Escorts Heart Institute and Research Center, New Delhi, India, ²Former Dept. of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ³Former Dept. of Psychiatry (Psychology Unit), All India Institute of Medical Sciences, New Delhi, India, ⁴Dept. of Psychiatry, All India Institute of Medical Sciences, New Delhi, India, ⁵Dept. of Neurology, Fortis Hospital, Vasant Kunj, New Delhi, India, ⁶Former Dept. of Neurology, All India Institute of Medical Sciences, New Delhi, India, ⁷Former Dept. of Linguistics, School of Language, Literature and Culture Studies, Jawaharlal Nehru University, New Delhi, India, ⁸Dept. of Biostatistics, All India Institute of Medical Sciences, New Delhi, India, ⁹Dept. of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India

Synopsis

Dyslexia is a neurodevelopmental disorder with complex spectrum and continuum of cognitive deficits leading to academic and emotional life-long burden, so optimal remediation becomes essential and challenging. Pre- and post- functional imaging studies show the recovery changes in brain with rehabilitation, but can fMRI biomarkers be explored and utilized for customizing therapeutic strategies in dyslexia. In present study at baseline we randomly allocated dyslexic children to therapy (Rx) and waitlist (nonRx) groups. Based on the potential (positive and negative) neural-markers at baseline, we tailored cognitive modules for phonological intervention. Remediation resulted in improved performance and cortical normalization

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