Abstract #2941
Post-Therapy cortical normalization for phonological processing in developmental dyslexia
Sunita Gudwani1,2, Manju Mehta3, Rajesh Sagar4, Madhuri Behari5,6, Vaishna Narang7, Sadanad Sadanad Dwivedi8, N.R. Jagannathan2, and S.Senthil Kumaran9
1Dept. of NeuroRehab, speech therapy and audiology, Escorts Heart Institute and Research Center, New Delhi, India, 2Former Dept. of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 3Former Dept. of Psychiatry (Psychology Unit), All India Institute of Medical Sciences, New Delhi, India, 4Dept. of Psychiatry, All India Institute of Medical Sciences, New Delhi, India, 5Dept. of Neurology, Fortis Hospital, Vasant Kunj, New Delhi, India, 6Former Dept. of Neurology, All India Institute of Medical Sciences, New Delhi, India, 7Former Dept. of Linguistics, School of Language, Literature and Culture Studies, Jawaharlal Nehru University, New Delhi, India, 8Dept. of Biostatistics, All India Institute of Medical Sciences, New Delhi, India, 9Dept. of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India
Synopsis
Dyslexia is a neurodevelopmental disorder with complex spectrum and continuum of cognitive deficits leading to academic and emotional life-long burden, so optimal remediation becomes essential and challenging. Pre- and post- functional imaging studies show the recovery changes in brain with rehabilitation, but can fMRI biomarkers be explored and utilized for customizing therapeutic strategies in dyslexia. In present study at baseline we randomly allocated dyslexic children to therapy (Rx) and waitlist (nonRx) groups. Based on the potential (positive and negative) neural-markers at baseline, we tailored cognitive modules for phonological intervention. Remediation resulted in improved performance and cortical normalization
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