Abstract #2945

Increased Brain Iron Deposition in Moderate and Severe Obstructive Sleep Apnea using Quantitative Susceptibility Mapping

Xinchun Li¹, Peng Wang¹, Qi Wan¹, Yihao Guo², Jianfeng Hu¹, Yu Peng¹, Xiaoying Xia¹, Jieqiong Liu¹, Xiaobin Xie¹, and Mengzhu Wang³

¹Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, ²MR Collaboration, Siemens Healthineers Ltd., Guangzhou, China, ³MR Scientific Marketing, Siemens Healthineers, Guangzhou, China

Synopsis

In the current study, we assessed the possible alterations of iron accumulation in the brain of patients with Obstructive Sleep Apnea (OSA) using quantitative susceptibility mapping (QSM). We found that there was increased iron accumulation in the bilateral hippocampus for patients with OSA, compared to controls. And the QSM value of the bilateral hippocampus was related to the course of disease in patients with OSA. The QSM values of the right hippocampus were correlated with multiple clinical indicators and may therefore be used as potential biomarkers to further understand the pathophysiological mechanisms of moderate to severe OSA.

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