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Abstract #2945

Increased Brain Iron Deposition in Moderate and Severe Obstructive Sleep Apnea using Quantitative Susceptibility Mapping

Xinchun Li1, Peng Wang1, Qi Wan1, Yihao Guo2, Jianfeng Hu1, Yu Peng1, Xiaoying Xia1, Jieqiong Liu1, Xiaobin Xie1, and Mengzhu Wang3
1Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, 2MR Collaboration, Siemens Healthineers Ltd., Guangzhou, China, 3MR Scientific Marketing, Siemens Healthineers, Guangzhou, China


In the current study, we assessed the possible alterations of iron accumulation in the brain of patients with Obstructive Sleep Apnea (OSA) using quantitative susceptibility mapping (QSM). We found that there was increased iron accumulation in the bilateral hippocampus for patients with OSA, compared to controls. And the QSM value of the bilateral hippocampus was related to the course of disease in patients with OSA. The QSM values of the right hippocampus were correlated with multiple clinical indicators and may therefore be used as potential biomarkers to further understand the pathophysiological mechanisms of moderate to severe OSA.

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