Abstract #2944

Correlation between GABA+ levels in mPFC and topological characters of EEG functional connectivity network during light sleep in young adults

Sihui Zhao¹, Yanting Liu¹, Yanan Gao¹, bing Yu², Mikkelsen Mark³, Hui Steve³, Edden A.E Richard³, and Chen Zhang⁴

¹China Medical University, Shenyang, China, ²Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China, ³Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴MR Scientific Marketing, Siemens Healthineers, Beijing, China

Synopsis

The aim of our study is to explore the relationship between GABA levels of medial prefrontal cortex （mPFC）and the topological characters of cerebral EEG functional connectivity network in young adults during sleep using Hadamard Encoding and Reconstruction of Mega-Edited Spectroscopy (HERMES) method. Synchronous EEG-MRS data were acquired from 37 young adults. GABA+ level in mPFC and the global topological characters of the EEG functional connectivity network were calculated. The results demonstrated a significant negative correlation between global efficiency of EEG functional connectivity network in delta bandand and GABA+ levels in mPFC during N2 sleep stage.

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