Measurement of Cerebrospinal fluid and Interstitial Fluid Flow in Mouse Brain using Q-space Imaging
Satoshi Yatsushiro1,2, Anju Satou3, Mitsunori Matsumae4, Hideki Atsumi4, Tomohiko Horie5, and Kagayaki Kuroda1,3
1Human and Information Science, Tokai university, Hiratsuka, Kanagawa, Japan, 2BioView, Inc., Tokyo, Japan, 3Electrical and Electronic Engineering, Tokai university, Hiratsuka, Kanagawa, Japan, 4Neurosurgery, Tokai university, Isehara, Kanagawa, Japan, 5Radiological Technology, Tokai university hospital, Isehara, Kanagawa, Japan
To visualize cerebrospinal fluid (CSF) and interstitial fluid (ISF) flows, in this study, q-space imaging (QSI) based on 3-dimensional stimulated echo and echo planar imaging (3D STE-EPI) was performed for mouse brain. QSI can measure velocity of flow as µm/s order. The preliminary results showed the CSF and ISF flows in the mouse brain. In addition, the technique seemed to exhibit the CSF/ISF flows along the corpus callosum of the mouse brain. In the future, QSI with STE-EPI may quantitatively reveal the CSF and ISF flows in human brain.
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