Abstract #2943

Measurement of Cerebrospinal fluid and Interstitial Fluid Flow in Mouse Brain using Q-space Imaging

Satoshi Yatsushiro^1,2, Anju Satou³, Mitsunori Matsumae⁴, Hideki Atsumi⁴, Tomohiko Horie⁵, and Kagayaki Kuroda^1,3

¹Human and Information Science, Tokai university, Hiratsuka, Kanagawa, Japan, ²BioView, Inc., Tokyo, Japan, ³Electrical and Electronic Engineering, Tokai university, Hiratsuka, Kanagawa, Japan, ⁴Neurosurgery, Tokai university, Isehara, Kanagawa, Japan, ⁵Radiological Technology, Tokai university hospital, Isehara, Kanagawa, Japan

Synopsis

To visualize cerebrospinal fluid (CSF) and interstitial fluid (ISF) flows, in this study, q-space imaging (QSI) based on 3-dimensional stimulated echo and echo planar imaging (3D STE-EPI) was performed for mouse brain. QSI can measure velocity of flow as µm/s order. The preliminary results showed the CSF and ISF flows in the mouse brain. In addition, the technique seemed to exhibit the CSF/ISF flows along the corpus callosum of the mouse brain. In the future, QSI with STE-EPI may quantitatively reveal the CSF and ISF flows in human brain.

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