Cognitive deficits are prominent non-motor symptoms in Parkinson’s disease (PD) and have been involved with neurovascular unit. However, sufficient neuroimaging studies are lacked investigating the associated modulating mechanisms. This study aimed to identify the contribution of neurovascular decoupling to the pathogenesis of cognitive decline in PD by integrating informative data obtained from the blood oxygen level-dependent and arterial-spin-labeling approaches. The involvement of neurovascular decoupling in cognitive impairment in PD is regionally specific and most prominent in the visual-spatial cortices, which could potentially provide a complementary understanding for the pathophysiological mechanisms underlying cognitive deficits in PD.
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