Cognitive deficits are prominent non-motor symptoms in Parkinson’s disease (PD) and have been involved with neurovascular unit. However, sufficient neuroimaging studies are lacked investigating the associated modulating mechanisms. This study aimed to identify the contribution of neurovascular decoupling to the pathogenesis of cognitive decline in PD by integrating informative data obtained from the blood oxygen level-dependent and arterial-spin-labeling approaches. The involvement of neurovascular decoupling in cognitive impairment in PD is regionally specific and most prominent in the visual-spatial cortices, which could potentially provide a complementary understanding for the pathophysiological mechanisms underlying cognitive deficits in PD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords