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Abstract #2953

Structural and functional changes of the cerebellum in patients with Parkinson's disease: a VBM and rs-fMRI study

xiu Cheng1, jun Wang1, pengfei Zhang1, jing Zhang1, kai Ai2, and wanjun Hu1
1Lanzhou University Second Hospital, Lanzhou, China, 2Philips Healthcare, Xi'an, China


To investigate the structural and functional alterations of cerebellum in patients with Parkinson's disease (PD) using voxel-based morphometry and resting-state functional MRI. We analyzed alterations gray matter volume (GMV), regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF) in the cerebellum of PD patients. Furthermore, the correlation analysis between GMV, ALFF, ReHo values and clinical scale scores was performed. Our results showed that the structure and function of the cerebellum of PD patients are significantly different from healthy controls (HC), and these changes are significantly correlated with clinical scales scores, which suggested that the cerebellum plays an important role in PD.

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