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Abstract #2954

Gray matter myelin quantification in Parkinson’s disease based on MP2RAGE T1 mapping

Yu Shen1, Yan Bai1, Xianchang Zhang2, Yaping Wu1, Yu Luo1, Zhun Huang1, Xipeng Yue1, Menghuan Zhang1, and Meiyun Wang1
1Henan Provincial People's Hospital, Zhengzhou, China, 2MR Collaboration, Siemens Healthineers Ltd, Beijing, China


Quantitative R1(1/T1) imaging has been proposed as surrogate imaging biomarkers for myelin content in cortical gray matter. This study, using high resolution T1 maps generated by MP2RAGE sequence, quantified gray matter myelin in Parkinson’s disease (PD) patients and compared the values with those in healthy controls. The results revealed that myelin (represented by R1) was significantly decreased in PD in several cortical and subcortical brain areas, which may be anatomic evidence for the spectrum of symptoms in PD, such as deficits of memory, mood, and cognition. Myelin quantification based on MP2RAGE-T1 mapping may be a valuable biomarker for characterizing PD.

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