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Abstract #2955

Distinct patterns of tremor network microstructure for essential tremor and Parkinson’s disease

Thomas Welton1,2, Amadis Aliya Ong3, Septian Hartono1,2, Yao-Chia Shih4, Amanda Lee3, Eng-King Tan1,5, and Ling Ling Chan1,3
1National Neuroscience Institute, Singapore, Singapore, 2Duke-NUS Graduate Medical School, Singapore, Singapore, 3Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, 4Graduate Institute of Medicine, Yuan Ze University, Taiwan, Taiwan, 5Neurology, Singapore General Hospital, Singapore, Singapore


Differential diagnosis of essential tremor and Parkinson’s disease can be challenging due to overlapping clinical presentations, but these diseases differ in neuropathological features, which may be detected using diffusion spectrum imaging. We identified parts of a tremor-related cerebello-thalamo-cortical network based on diffusion spectrum imaging that differed among a cohort comprising essential tremor and Parkinson’s patients, and healthy-controls. The patient groups had minimally-overlapping areas of abnormal microstructure in the tremor-network, and these were significantly correlated with clinical and kinetic measures of tremor severity. A future DSI-based marker of tremor-network microstructure may aid in differential diagnosis of essential tremor and Parkinson’s disease.

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