It has been overlooked in clinical that there exists a complex relationship between laterality and motor symptoms in Parkinson’s disease (PD) and these factors may influence their motor and nonmotor symptoms in together. Here we found PD with left-side akinetic/rigid (L-AR) signs performed worst in clinical manifestations. And the underlying brain structure alterations was revealed severer damage in anterior cingulate and its connected fibers of right hemisphere by a multimodal imaging approach including cortical thickness and diffusion-weighted MRI measures.
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