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Abstract #2956

Gray and white matter alterations in different predominant side and type of motor symptom in Parkinson’ disease

Jingwen Chen1, Cheng Zhou1, Jingjing Wu1, Tao Guo1, Xueqin Bai1, Haoting Wu1, Xiaocao Liu1, Jiaqi Wen1, Zhengye Cao1, Yong Zhang2, Xiaojun Guan1, Xiaojun Xu1, and Minming Zhang1
1Radiology, The second affiliated hospital, Zhejiang University school of medicine, Hangzhou, China, 2GE Healthcare, Shanghai, China


It has been overlooked in clinical that there exists a complex relationship between laterality and motor symptoms in Parkinson’s disease (PD) and these factors may influence their motor and nonmotor symptoms in together. Here we found PD with left-side akinetic/rigid (L-AR) signs performed worst in clinical manifestations. And the underlying brain structure alterations was revealed severer damage in anterior cingulate and its connected fibers of right hemisphere by a multimodal imaging approach including cortical thickness and diffusion-weighted MRI measures.

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