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Abstract #2958

Altered Visual Network and Global Fluctuation in the Resting-state fMRI of Patients with Parkinson’s Disease

Destaw Bayabil Mekbib1, Weiying Dai2, Miao Cai3, Xiaoli Liu3, and Li Zhao1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China, 2Computer Science, Binghamton Univeristy, State University of New York, Binghamton, NY, United States, 3Neurology, Zhejiang Hospital, Hangzhou, China


Resting-state fMRI plays an increasing role in understanding the neural mechanisms of Parkinson's disease (PD). However, neural network alterations, regional and global signal associations are not fully understood in PD patients. Here, we studied the whole-brain neural networks including the inter-network and their correlations with the global fluctuation in 37 PD patients and 20 healthy controls. Our findings revealed that the visual cortex had reduced neural network connectivity in PD patients and altered connections from default mode network to other networks. Weaker correlations were observed between the global signal and regional networks in the PD patients than healthy controls.

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