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Abstract #2962

Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease: an integrated MRI study

Song'an Shang1, Weiqiang Dou2, and Jingtao Wu3
1Nanjing First Hospital, Nanjing Medical University, Nanjing, China, 2GE Healthcare, MR Research China, Beijing, China, 3Clinical Medical College, Yangzhou University, Yangzhou, China


For Parkinson’s disease (PD), the time-varying properties of functional coherence and their coupling to regional perfusion are rarely elucidated. We aimed to investigate early disruption of dynamic regional homogeneity (dReho) pattern and neurovascular coupling (NC) in PD patients before onset of cognitive impairment and their classification performance. PD patients at early stage exhibited an impaired dynamic pattern of neuronal synchronization and disrupted NC. The features of CBF/dReho provided robust performance in differentiating PD from healthy controls. With this findings, the insights into early pathophysiological mechanism underlying PD from regional dynamic pattern and NC were reinforced.

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