Abstract #2966

Fixel-Based Analysis of White Matter Degeneration in Patients with Progressive Supranuclear Palsy and Corticobasal Syndrome

Wataru Uchida¹, Koji Kamagata¹, Christina Andica¹, Yuya Saito¹, Kaito Takabayashi¹, Akifumi Hagiwara¹, Shohei Fujita^1,2, Toshiaki Akashi¹, Akihiko Wada¹, Masaaki Hori³, and Shigeki Aoki¹

¹Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, ²Department of Radiology, The University of Tokyo, Tokyo, Japan, ³Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan

Synopsis

Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are neurodegenerative disorders associated with corticobasal degeneration pathology. A previous study evaluated white matter (WM) alteration using diffusion tensor imaging; however, the details are unclear due to the crossing fiber. This study evaluated cross-sectional and longitudinal WM changes in PSP and CBS using fixel-based analysis. This study also demonstrated consistent cross-sectional and longitudinal WM degeneration with previous histopathological studies and higher sensitivity than classical magnetic resonance imaging findings in differentiating PSP and CBS. Our results suggest that FBA can be a biomarker to classify PSP and CBS and estimate disease progression.

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