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Abstract #2966

Fixel-Based Analysis of White Matter Degeneration in Patients with Progressive Supranuclear Palsy and Corticobasal Syndrome

Wataru Uchida1, Koji Kamagata1, Christina Andica1, Yuya Saito1, Kaito Takabayashi1, Akifumi Hagiwara1, Shohei Fujita1,2, Toshiaki Akashi1, Akihiko Wada1, Masaaki Hori3, and Shigeki Aoki1
1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Radiology, The University of Tokyo, Tokyo, Japan, 3Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan


Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are neurodegenerative disorders associated with corticobasal degeneration pathology. A previous study evaluated white matter (WM) alteration using diffusion tensor imaging; however, the details are unclear due to the crossing fiber. This study evaluated cross-sectional and longitudinal WM changes in PSP and CBS using fixel-based analysis. This study also demonstrated consistent cross-sectional and longitudinal WM degeneration with previous histopathological studies and higher sensitivity than classical magnetic resonance imaging findings in differentiating PSP and CBS. Our results suggest that FBA can be a biomarker to classify PSP and CBS and estimate disease progression.

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