White matter microstructure alterations using Generalized Q-Sampling Imaging in Moderate and Severe Obstructive Sleep Apnea
Peng Wang1, Xinchun Li1, Qi Wan1, Wenjin Zou2, Yihao Guo3, Mengzhu Wang4, Jianfeng Hu1, Yu Peng1, Xiaoying Xia1, Xiaobin Xie1, and Jieqiong Liu1
1Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, 2The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China, 3MR Collaboration, Siemens Healthineers Ltd., Guangzhou, China, 4MR Scientific Marketing, Siemens Healthineers, Guangzhou, China
In the current study, we assessed possible alterations of brain white matter (WM) microstructure in patients with obstructive sleep apnea (OSA) using generalized q-sampling imaging (GQI). We found higher normalized quantitative anisotropy values of the bilateral superior longitudinal fasciculus, uncinate fasciculus, fornix, and corpus callosum bundle in the OSA group vs controls, which were related to multiple clinical indices of OSA.
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