Based on the multi-shell diffusion MRI data acquisition and tract-based spatial statistics (TBSS), we conducted a longitudinal study to explore the changing patterns of DKI and NODDI metrics after radiotherapy for nasopharyngeal carcinoma (NPC) patients. We found most of the significant regions showed a “self-recovery” mechanism but the temporal lobe regions show a progressive changing pattern over time after RT. Besides, we also found that the change of DKI metrics has a stronger dose-correlation than DTI and NODDI metrics. Our study indicates the DKI and NODDI metrics can provide more comprehensive brain microstructure changes compared with conventional DTI.
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