Abstract #2968

Radiation-induced White Matter Abnormalities in Nasopharyngeal Carcinoma: Evaluation by DKI and NODDI

Yuhao Lin¹, Xiaofei Lv², Jiahui Liang², Yanqiu Feng¹, and Xinyuan Zhang¹

¹School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ²Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China

Synopsis

Based on the multi-shell diffusion MRI data acquisition and tract-based spatial statistics (TBSS), we conducted a longitudinal study to explore the changing patterns of DKI and NODDI metrics after radiotherapy for nasopharyngeal carcinoma (NPC) patients. We found most of the significant regions showed a “self-recovery” mechanism but the temporal lobe regions show a progressive changing pattern over time after RT. Besides, we also found that the change of DKI metrics has a stronger dose-correlation than DTI and NODDI metrics. Our study indicates the DKI and NODDI metrics can provide more comprehensive brain microstructure changes compared with conventional DTI.

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