Meeting Banner
Abstract #2968

Radiation-induced White Matter Abnormalities in Nasopharyngeal Carcinoma: Evaluation by DKI and NODDI

Yuhao Lin1, Xiaofei Lv2, Jiahui Liang2, Yanqiu Feng1, and Xinyuan Zhang1
1School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China


Based on the multi-shell diffusion MRI data acquisition and tract-based spatial statistics (TBSS), we conducted a longitudinal study to explore the changing patterns of DKI and NODDI metrics after radiotherapy for nasopharyngeal carcinoma (NPC) patients. We found most of the significant regions showed a “self-recovery” mechanism but the temporal lobe regions show a progressive changing pattern over time after RT. Besides, we also found that the change of DKI metrics has a stronger dose-correlation than DTI and NODDI metrics. Our study indicates the DKI and NODDI metrics can provide more comprehensive brain microstructure changes compared with conventional DTI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here