Meeting Banner
Abstract #2969

Role of the superficial white matter in processing speed decline in cerebral small vessel disease

Shuyue Wang1, Fan Zhang2, Peiyu Huang1, Hui Hong1, Yeerfan Jiaerken1, Xinfeng Yu1, Ruiting zhang1, Qingze Zeng1, Yao Zhang1, Ron Kikinis2, Yogesh Rathi2, Nikos Makris2, Ofer Pasternak2, Minming Zhang1, and Lauren J. O’Donnell2
1The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 2Harvard Medical School, Boston, MA, United States


We assess microstructural alterations in superficial white matter (SWM) in cerebral small vessel disease (CSVD) and evaluate their contributions to the decline in processing speed, which is the main dysfunction in CSVD. We identify that the significant decline in processing speed may relate to the involvement of WMH in the SWM under high burden of disease. The increased extracellular free water may be the main SWM microstructural change under low burden of disease. These observations suggest that the SWM may serve as a potential target for monitoring pathophysiological processes in CSVD. This study extends the current understanding of CSVD-related dysfunction.

This abstract and the presentation materials are available to members only; a login is required.

Join Here