Abstract #2969

Role of the superficial white matter in processing speed decline in cerebral small vessel disease

Shuyue Wang¹, Fan Zhang², Peiyu Huang¹, Hui Hong¹, Yeerfan Jiaerken¹, Xinfeng Yu¹, Ruiting zhang¹, Qingze Zeng¹, Yao Zhang¹, Ron Kikinis², Yogesh Rathi², Nikos Makris², Ofer Pasternak², Minming Zhang¹, and Lauren J. O’Donnell²

¹The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, ²Harvard Medical School, Boston, MA, United States

Synopsis

We assess microstructural alterations in superficial white matter (SWM) in cerebral small vessel disease (CSVD) and evaluate their contributions to the decline in processing speed, which is the main dysfunction in CSVD. We identify that the significant decline in processing speed may relate to the involvement of WMH in the SWM under high burden of disease. The increased extracellular free water may be the main SWM microstructural change under low burden of disease. These observations suggest that the SWM may serve as a potential target for monitoring pathophysiological processes in CSVD. This study extends the current understanding of CSVD-related dysfunction.

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