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Abstract #2971

Quantitative assessment of neonatal white matter injury stiffness by virtual magnetic resonance elastography

Miaomiao Wang1, Congcong Liu1, Xianjun Li1, and Jian Yang1
1the first affiliated hospital of Xi'an Jiaotong university, Xi'an, China


Punctate white matter lesion (PWML) is the most common injury in neonates. Due to newborns are a vulnerable population, the limited imaging protocols are not sufficient to fully understand the injury. Le Bihan recently proposed a virtual MR elastography (vMRE) method based on multiple b-values diffusion sequences, which is attractive for evaluation of brain development and injury. This study aims to quantitatively assess the stiffness of PWML using vMRE. Compared with white matter regions, a significant increased virtual sheer stiffness is observed in lesions, and it may be a feasible clinical evaluation of the pathophysiological state of brain tissue.

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