Abstract #2973

Inhomogeneous Magnetization Transfer (ihMT) Helps to Detect Multiple Sclerosis Plaques in The Spinal Cord.

Ryuna Kurosawa¹, Hajime Yokota², Takafumi Yoda¹, Takayuki Sada¹, Koji Matsumoto¹, Takashi Namiki³, Masami Yoneyama³, Guillaume Gilbert⁴, Yoshitada Masuda¹, and Takashi Uno²

¹Department of Radiology, Chiba Univercity Hospital, Chiba, Japan, ²Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan, ³Philips Japan, Tokyo, Japan, ⁴Philips Canada, Mississauga, ON, Canada

Synopsis

Demyelination assessment with MRI for multiple sclerosis (MS) is a reliable biomarker for monitoring disease progression. Recently, inhomogeneous magnetization transfer (ihMT) combined sequencing has been developed for myelin-specific imaging. The purpose of this study was to evaluate ihMT in delineating MS lesions in the spinal cord by comparing the conventional imaging methods. The lesion-to-white matter contrast-to-noise ratio (CNR) on ihMT was significantly higher than the other methods. The qualitative analysis revealed clarity of lesion detection, but false positives were a concern. Our results in MS patients suggest that ihMT may be a helpful sequence for lesion detection.

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