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Abstract #2973

Inhomogeneous Magnetization Transfer (ihMT) Helps to Detect Multiple Sclerosis Plaques in The Spinal Cord.

Ryuna Kurosawa1, Hajime Yokota2, Takafumi Yoda1, Takayuki Sada1, Koji Matsumoto1, Takashi Namiki3, Masami Yoneyama3, Guillaume Gilbert4, Yoshitada Masuda1, and Takashi Uno2
1Department of Radiology, Chiba Univercity Hospital, Chiba, Japan, 2Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan, 3Philips Japan, Tokyo, Japan, 4Philips Canada, Mississauga, ON, Canada


Demyelination assessment with MRI for multiple sclerosis (MS) is a reliable biomarker for monitoring disease progression. Recently, inhomogeneous magnetization transfer (ihMT) combined sequencing has been developed for myelin-specific imaging. The purpose of this study was to evaluate ihMT in delineating MS lesions in the spinal cord by comparing the conventional imaging methods. The lesion-to-white matter contrast-to-noise ratio (CNR) on ihMT was significantly higher than the other methods. The qualitative analysis revealed clarity of lesion detection, but false positives were a concern. Our results in MS patients suggest that ihMT may be a helpful sequence for lesion detection.

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