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Abstract #2974

Application of MRI in tracking and evaluating of SPIONS labeled stromal stem cells transplanted in traumatic spinal cord injury of beagle

Xiaoli Mai1, Jilei Zhang2, Junting Zou1, Yuanyuan Xie3, Bin Wang3, and Bing Zhang1
1Radiology Department, Nanjing Drum Tower Hospital, the affiliated hospital of Nanjing University Medical School, Nanjing, China, 2Philips Healthcare, Shanghai, China, 3Nanjing Drum Tower Hospital, Nanjing, China


Stromal cell transplantation plays an important role in the treatment of traumatic spinal cord injury (SCI). The multi-parameter MRI, including DTI, T2 , T2* mapping and QSM , of all beagles were performed before and after operation. We found that the transplanted stromal stem cells with Ruicun-labeled in the injured spinal cord could be quantified by QSM within 28 days after transplantation. FA value can be used to quantitatively evaluate the integrity of spinal fibers and the recovery of spinal nerve function. Thus, MRI can used to track the dynamic changes of SPIONS labeled stromal stem cells transplanted.

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