Abstract #2980

Focused ultrasound-modulated left dorsolateral prefrontal cortex of the non-human primate assessed by functional MRI

Yu Xu¹, Tingting He², Haiming Wang², Xiao Yu¹, Boyi Qu², Ssu-Ju Li³, and Hsin-Yi Lai⁴

¹Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, China, ²College of Biomedical Engineering & Instrument Science, Zhejiang University. Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University, Hangzhou, China, ³Department of Biomedical Engineering, National Yang Ming University, No. 155, Section 2, Linong Street, Taipei, 112, Taiwan, ROC. Department of Biomedical Engineering, National Yang Ming Chiao Tung University, No. 1001 Ta-Hsueh Rd., Hsinchu, 300, Taiwan, ROC, Taiwan, China, ⁴College of Biomedical Engineering & Instrument Science, Zhejiang University. Department of Neurology of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University. Department of Neurology of Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

Synopsis

Focused ultrasound (FUS) has shown its unique advantages in the field of non-invasive neuromodulation. The dorsolateral prefrontal cortex (DLPFC) is a key node in brain networks involved in cognitive, emotional and sensory processing. Here we evaluated the immediate and latency effects of DLPFC-FUS by functional magnetic resonance imaging (fMRI). The results showed that DLPFC-FUS induced a 3% increase in positive BOLD signal, and decreased FCs in bilateral primary and secondary visual cortices, supported by visual stimuli-evoked BOLD change. Moreover, FCs significantly decreased in left thalamus at 5-min post-FUS and in bilateral anterior cingulate cortex (ACC) at 30-min post-FUS. These results may help to elucidate the effect of FUS neuromodulation.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.