Focused ultrasound (FUS) has been considered as a noninvasive neuromodulation method. In addition to evaluate the functional connectivity (FC) by an average of BOLD signals across the whole scan, a dynamic FC (dFC) can help to comprehend the instant alternation of FC. We aimed to investigate the alterations of dFC after FUS-neuromodulation at VPM/VPL in a normal rat model.
We used k-means and dynamic network analyses to evaluate changes of dFC at Pre-FUS, Sham, 35-min, 3-hr, and 3-day for rats with FUS sonication at VPM/VPL. We found an instant effect of FUS-neuromodulation (35-min) and a recovering trend in 3-day.