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Abstract #2981

Analysis of Dynamic Function Connectivity in a Normal Rat Model After Focused Ultrasound-Neuromodulation in VPM/VPL

Yu-Chieh Hung1, Yi-Cheng Wang1, Hao-Li Liu2, and Hsu-Hsia Peng1
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan


Focused ultrasound (FUS) has been considered as a noninvasive neuromodulation method. In addition to evaluate the functional connectivity (FC) by an average of BOLD signals across the whole scan, a dynamic FC (dFC) can help to comprehend the instant alternation of FC. We aimed to investigate the alterations of dFC after FUS-neuromodulation at VPM/VPL in a normal rat model.

We used k-means and dynamic network analyses to evaluate changes of dFC at Pre-FUS, Sham, 35-min, 3-hr, and 3-day for rats with FUS sonication at VPM/VPL. We found an instant effect of FUS-neuromodulation (35-min) and a recovering trend in 3-day.

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