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Abstract #2989

Relationship between GABA+ level in occipital lobe and topological characters of cerebral EEG functional  connectivity network in young adults

Yanting Liu1, Sihui Zhao1, Yanan Gao1, Hui Steve2,3, Mikkelsen Mark2,3, A.E.Edden Richard2,3, Chen Zhang4, and Bing Yu1
1China Medical University, Shenyang, China, China, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA, Baltimore, MD, United States, 3F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA, Baltimore, MD, United States, 4MR Scientific Marketing, Siemens Healthineers, Beijing, China


We carried investigation to explore the relationship of GABA level of occipital lobe on topological and organizational properties of the entire brain using Hadamard Encoding and Reconstruction of Mega-Edited Spectroscopy (HERMES) method. Synchronous EEG-MRS data were obtained from forty healthy volunteers. GABA+ level and the global topological topological characters of the EEG functional connectivity network were calculated. The results demonstrate that the GABA+ level of the occipital lobe showed a significant negative correlation with the small world index of EEG functional connectivity network in the EEG α band.

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