Abstract #2989

Relationship between GABA+ level in occipital lobe and topological characters of cerebral EEG functional connectivity network in young adults

Yanting Liu¹, Sihui Zhao¹, Yanan Gao¹, Hui Steve^2,3, Mikkelsen Mark^2,3, A.E.Edden Richard^2,3, Chen Zhang⁴, and Bing Yu¹

¹China Medical University, Shenyang, China, China, ²Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA, Baltimore, MD, United States, ³F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA, Baltimore, MD, United States, ⁴MR Scientific Marketing, Siemens Healthineers, Beijing, China

Synopsis

We carried investigation to explore the relationship of GABA level of occipital lobe on topological and organizational properties of the entire brain using Hadamard Encoding and Reconstruction of Mega-Edited Spectroscopy (HERMES) method. Synchronous EEG-MRS data were obtained from forty healthy volunteers. GABA+ level and the global topological topological characters of the EEG functional connectivity network were calculated. The results demonstrate that the GABA+ level of the occipital lobe showed a significant negative correlation with the small world index of EEG functional connectivity network in the EEG α band.

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