Abstract #2988

Multiplex network analysis reveals disrupted brain processing speed in children with prenatal alcohol exposure

Xiaoyun Liang^1,2, Chun-Hung Yeh^3,4, and Peter J. Anderson^1,5

¹Victorian Infant Brain Study (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, ²Florey Department of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Australia, ³Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁴Department of Psychiatry, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁵Turner Institute for Brain and Mental Health, Monash University, Clayton, Australia

Synopsis

In this study, we applied a method that integrates dynamic functional connectivity using the multiplex network approach to enhance the sensitivity to subtle alterations of functional connectivity on participants subject to PAE. Our results demonstrated its capability in characterizing subtle brain network changes in children with low-moderate PAE. The lower values of the PAE T1-T3 group indicates that the information processing speed could have been compromised due to PAE. In line with literature, the distinct findings between male and female groups revealed that PAE may induce gender-dependent brain disruptions and males are more susceptible to PAE.

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