The neural correlations that characterize hopelessness may help identify brain mechanisms and individuals at risk of depression and suicide. Here, we examined the functional connectivity (FC) patterns of resting state associated with hopelessness in healthy later adolescents and young adults by using CPM. We found that the level of hopelessness was negatively correlated with the FC between the right MTG and the bilateral PoG and PrG, as well as the FC between the right cerebellum VI and the left thalamus. The finding suggested that cortical-cerebellum networks underlying negative future expectation processing characterized hopelessness.
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