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Abstract #2993

Effect of caffeine on cerebral hemodynamic response: The modulation of dietary caffeine consumption

Shin-Lei Peng1, Lok Wang Lauren Chu1, and Feng-Yi Su2
1Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, China Medical University, Taichung, Taiwan, 2Department of Medical Imaging, China Medical University Hospital, Taichung, Taiwan


The main aim of this study was to characterize the acute effect of caffeine on cerebral hemodynamic responses in participants with different caffeine consumption habits. The non-habitual group exhibited a larger degree of vasoconstriction and thus diminished the ability to dilate upon stimulation. As the vessel dilation ability has been considered as a covariate to explain variabilities in fMRI signals, our results may suggest that the suppressed BOLD response to a visual stimulation in low-caffeine-level users could be partially attributed to the decreased vascular reactivity altered by the baseline perfusion.

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