Abstract #2999

Thalamus regulates emotional performance in different pathways with CSVD involved

Bei Wang¹, Cen Guo², He Wang^1,3, Yan Han², and Ying-Hua Chu⁴

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China, ³Human Phenome Institute, Fudan University, Shanghai, China, ⁴MR Collaboration, Siemens Healthineers Ltd., Shanghai, China

Synopsis

With the help of 7T Imaging, we investigated the association between the thalamic anterior vascularization patterns and emotions, including depression and anxiety. Cerebral small vessel diseases were considered as a risk factor for emotional performance. The thalamic anterior vascularization pattern was found association with depression and anxiety in subjects without CSVD burden. In the CSVD group, the thalamic volume and cortex thickness in pars triangularis, rostral middle frontal and superior frontal were found significantly correlated with both HAMD and HAMA test scores. It suggests the pathway of the thalamus regulating emotion changes with the development of CSVD.

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