Aberrant cortical gyrification in adolescent major depressive disorder
Weijie Bao1, Lingxiao Cao1, Ruohan Feng1,2, Yingxue Gao1, Hailong Li1, Xinyue Hu1, Hui Qiu1, Kaili Liang1, Zilin Zhou1, and Xiaoqi Huang1,3
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of radiology, the Thrid Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China, Mianyang, China, 3Psychoradiology Research Unit of the Chinese Academy of Medical Sciences (2018RU011), West China Hospital of Sichuan University, Chengdu, Sichuan, China, Chengdu, China
Evidence has emerged to suggest the important role of cortical gyrification morphology in adult major depressive disorder (MDD). However, little is known about how the altered cortical gyrification contribute to adolescent patients who is at a critical period of brain development. We address this gap by examining the difference of local gyrification index (LGI) between adolescent MDD patients and HCs. We found that MDD patients showed significant increased LGI in the left PCC and bilateral lingual gyrus, which characterize the neurobiological mechanisms of adolescent MDD and may be important to understand the developmental effect of this disorder.
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