Evidence has emerged to suggest the important role of cortical gyrification morphology in adult major depressive disorder (MDD). However, little is known about how the altered cortical gyrification contribute to adolescent patients who is at a critical period of brain development. We address this gap by examining the difference of local gyrification index (LGI) between adolescent MDD patients and HCs. We found that MDD patients showed significant increased LGI in the left PCC and bilateral lingual gyrus, which characterize the neurobiological mechanisms of adolescent MDD and may be important to understand the developmental effect of this disorder.
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