Numerous neuroimaging studies have revealed abnormalities in specific brain regions in obsessive-compulsive disorder (OCD), but results have been inconsistent. We conducted a whole-brain voxel-wise meta-analysis on resting-state functional imaging and VBM studies between OCD patients and HCs by using Seed-based d Mapping (SDM) software. The meta-analysis demonstrated that OCD exhibits similar abnormalities in both function and structure in the prefrontal and insula. Few regions exhibited only functional or only structural abnormalities in OCD. These results expand the current understanding of functional and structural brain abnormalities in OCD patients, which would provide additional potential targets for therapeutic intervention.