We investigated the alteration of white matter in obsessive compulsive disorder from voxel-level, tractography-level and connectome-level by combining analysis of TBSS, AFQ and graph theory. TBSS and AFQ revealed widespread changes in WM. Network-based statistic (NBS) analysis demonstrated decreased structural connectivity in patients mainly comprising frontal, temporal, limbic areas, which belong to DMN, FPN, limbic, SMN and VAN network. Along with regions commonly described in the CSTC model of pathophysiology, our results indicate an involvement of white matter in frontal-temporal and limbic regions to differentiate OCD patients and healthy controls, supporting their importance for neurobiological alterations in OCD.
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