We investigated the alteration of white matter in obsessive compulsive disorder from voxel-level, tractography-level and connectome-level by combining analysis of TBSS, AFQ and graph theory. TBSS and AFQ revealed widespread changes in WM. Network-based statistic (NBS) analysis demonstrated decreased structural connectivity in patients mainly comprising frontal, temporal, limbic areas, which belong to DMN, FPN, limbic, SMN and VAN network. Along with regions commonly described in the CSTC model of pathophysiology, our results indicate an involvement of white matter in frontal-temporal and limbic regions to differentiate OCD patients and healthy controls, supporting their importance for neurobiological alterations in OCD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords