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Abstract #3005

Alteration in White Matter Microstructural Integrity and Network Differentiate Drug-naïve Obsessive compulsive disorder and Healthy controls

Suming Zhang 1, Xinyu Hu2, Xuan Bu2, Hailong Li1, LingXiao Cao2, Jing Liu2, KaiLi Liang2, Xue Li3, and Xiaoqi Huang2
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu City, China, 2Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, ChengDu City, China, 3College of Physics, Sichuan University,Chengdu, China, Chengdu City, China

Synopsis

We investigated the alteration of white matter in obsessive compulsive disorder from voxel-level, tractography-level and connectome-level by combining analysis of TBSS, AFQ and graph theory. TBSS and AFQ revealed widespread changes in WM. Network-based statistic (NBS) analysis demonstrated decreased structural connectivity in patients mainly comprising frontal, temporal, limbic areas, which belong to DMN, FPN, limbic, SMN and VAN network. Along with regions commonly described in the CSTC model of pathophysiology, our results indicate an involvement of white matter in frontal-temporal and limbic regions to differentiate OCD patients and healthy controls, supporting their importance for neurobiological alterations in OCD.

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