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Abstract #3006

Simultaneous PET-MRI reveals differences in aerobic glycolysis in temporal lobe versus extra temporal lobe epilepsy

Qikai Qin1,2, Miao Zhang3, Biao Li3,4, and Garth John Thompson1
1iHuman Institute, ShanghaiTech University, Shanghai, China, 2School of Life Science and Technology, ShanghaiTech University, Shanghai, China, 3Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 4Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Ruijin Center, Shanghai, China


Locating epileptic foci is critical for surgery in drug-resistant epilepsy. However, conventional methods (MRI, PET, SEEG) often cannot provide sufficient information alone. We have developed a new method, relative oxygen-glucose index (OGI), based on simultaneous PET and calibrated fMRI, which we used as a biomarker to locate epileptic foci during inter-ictal period. Relative OGI reflects aerobic glycolysis relative to global levels, which is useful as many diseases are characterized by metabolic pathway alterations. In this study, we not only demonstrate its potential in foci localization in epilepsy, but also distinguish temporal-lobe and extra-temporal-lobe epilepsy based on their different pathogenesis.

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