Locating epileptic foci is critical for surgery in drug-resistant epilepsy. However, conventional methods (MRI, PET, SEEG) often cannot provide sufficient information alone. We have developed a new method, relative oxygen-glucose index (OGI), based on simultaneous PET and calibrated fMRI, which we used as a biomarker to locate epileptic foci during inter-ictal period. Relative OGI reflects aerobic glycolysis relative to global levels, which is useful as many diseases are characterized by metabolic pathway alterations. In this study, we not only demonstrate its potential in foci localization in epilepsy, but also distinguish temporal-lobe and extra-temporal-lobe epilepsy based on their different pathogenesis.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords