Abstract #3008

Abnormal dynamic functional connectivity in new-onset, drug-naïve adolescent idiopathic generalized epilepsy

Yizhi Yuan^1,2, Yuting Wang^2,3, Jingping Mou³, Lan Mei^2,3, Chunyang Liu³, and Lihua Qiu^1,2,3

¹Department of Radiology, Chengdu Medical College, Chengdu, China, ²Department of Radiology, The Second People’s Hospital of Yibin, Yibin, China, ³Department of Radiology, Southwest Medical University, Luzhou, China

Synopsis

Dynamic functional connectivity (dFC) is a newly developed analysis strategies which could provide novel understandings of the pathophysiological mechanisms of neuropsychiatric disease. 45 adolescents diagnosed with IGE and 32 well-matched healthy controls completed this study using dynamic functional connectivity (dFC). The decreased dFC between two seed regions(MCC and ParaHipp) and PCC and IPL were part of default mode network(DMN). The impaired DMN in adolescent IGE patients suggest dFC might be more sensitive to reflect the changes of brain function in the early stage of disease and dFC analysis was a promising avenue to deepen our understanding of this disease.

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