Abstract #3011

Microscopic Fractional Anisotropy Estimation of Spinal Cord in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Masaaki Hori^1,2, Kouhei Kamiya^1,2,3, Akifumi Hagiwara², Kazumasa Yokoyama⁴, Issei Fukunaga⁵, Sano Katsuhiro², Koji Kamagata², Murata Katsutoshi⁶, Shohei Fujita², Christina Andica², Akihiko Wada², Julien Cohen-Adad⁷, and Shigeki Aoki²

¹Radiology, Toho University Omori Medical Center, Tokyo, Japan, ²Radiology, Faculty of Medicine, Juntendo University, Tokyo, Japan, ³Radiology, Tokyo University, Tokyo, Japan, ⁴Neurology, Faculty of Medicine, Juntendo University, Tokyo, Japan, ⁵Radiological Technology,, Faculty of Health Science, Juntendo University, Tokyo, Japan, ⁶Siemens Japan K.K., Tokyo, Japan, ⁷NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada

Synopsis

We investigated the microstructural changes in the spinal cords of patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using micro fractional anisotropy (μFA) derived from both double diffusion encoding (DDE) and 2-shell single diffusion encoding data with spherical mean techniques (SMT). There was no significant difference in μFA between MS and NMO. SMTs were not correlated with μFA derived from DDE. Therefore, SMT may be better treated as a separate diffusion MRI metric from μFA to investigate the microstructural alterations of spinal cord in patients with MS and NMOSD in vivo.

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