Microscopic Fractional Anisotropy Estimation of Spinal Cord in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
Masaaki Hori1,2, Kouhei Kamiya1,2,3, Akifumi Hagiwara2, Kazumasa Yokoyama4, Issei Fukunaga5, Sano Katsuhiro2, Koji Kamagata2, Murata Katsutoshi6, Shohei Fujita2, Christina Andica2, Akihiko Wada2, Julien Cohen-Adad7, and Shigeki Aoki2
1Radiology, Toho University Omori Medical Center, Tokyo, Japan, 2Radiology, Faculty of Medicine, Juntendo University, Tokyo, Japan, 3Radiology, Tokyo University, Tokyo, Japan, 4Neurology, Faculty of Medicine, Juntendo University, Tokyo, Japan, 5Radiological Technology,, Faculty of Health Science, Juntendo University, Tokyo, Japan, 6Siemens Japan K.K., Tokyo, Japan, 7NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada
We investigated the microstructural changes in the spinal cords of patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using micro fractional anisotropy (μFA) derived from both double diffusion encoding (DDE) and 2-shell single diffusion encoding data with spherical mean techniques (SMT). There was no significant difference in μFA between MS and NMO. SMTs were not correlated with μFA derived from DDE. Therefore, SMT may be better treated as a separate diffusion MRI metric from μFA to investigate the microstructural alterations of spinal cord in patients with MS and NMOSD in vivo.
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