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Abstract #3014

Exploring Development Trajectories of White Matter through MR imaging-based Virtual Elastography in Children

Congcong Liu1, Miaomiao Wang1, Xianjun Li1, Yao Ge1, and Jian Yang1
1the Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China


Characterizing development trajectories of white matter (WM) is vital for identifying causes of neurodevelopmental disorders. Besides DKI, MRE depicted mechanical properties of brain as a sensitive technique. But WM development trajectories of children were lack of researches on MRE. Therefore, we aimed to investigate age-related development of WM based on virtual elastography, comparing with DKI. We found virtual shear stiffness of WM was positively correlated with age, particularly presenting rapid-growth period of WM before 4-years old, consistent with changes of MK, FA. Virtual elastography may be potentially a valuable technique for depicting WM development trajectories, complementary to diffusion metrics.

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