Characterizing development trajectories of white matter (WM) is vital for identifying causes of neurodevelopmental disorders. Besides DKI, MRE depicted mechanical properties of brain as a sensitive technique. But WM development trajectories of children were lack of researches on MRE. Therefore, we aimed to investigate age-related development of WM based on virtual elastography, comparing with DKI. We found virtual shear stiffness of WM was positively correlated with age, particularly presenting rapid-growth period of WM before 4-years old, consistent with changes of MK, FA. Virtual elastography may be potentially a valuable technique for depicting WM development trajectories, complementary to diffusion metrics.
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