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Abstract #3013

Micro- and macro-structural alterations of white matter following sleep deprivation: a longitudinal fixel-based analysis

Chunxiang Jiang1,2,3, Marco Bigica3, Ilenia D’Onofrio3, Zhishan Liu3, Lijuan Zhang1, and Chen Song3,4
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 4University of Wisconsin-Madison, Madison, WI, United States


We examined the effect of sleep deprivation (SD) on human brain white matter(WM) using advanced fixel-based analysis. MRI data collected at four morning time points (7-8am, before and after SD, one night recovery and 3 days recovery). Compared to the session before SD, several WM tracts involving in sleep and wakefulness regulation, memory consolidation and emotion response showed varied fiber density (FD), fiber cross-section (FC) and the combined measure of FD and FC (termed FDC) at different time points. These findings demonstrated the heterogeneous sensitivity of WM tracts in response to SD and the microstructural homeostasis.

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