We aimed to measure diffusion parameters along the uncinate fasciculus and examine the specific and focal alterations of the uncinate fasciculus in first-episode and drug-naïve patients with major depressive disorder in adolescents by using a tract-based quantitative technique. Notably, we found the opposite alterations of the diffusion metrics in the insular and frontal segments of left uncinate fasciculus in adolescents with depression. It will help us to better understand the neurobiological mechanisms of adolescent depression and optimize adolescent-specific treatments for depression.
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