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Abstract #3017

Disruption on specific segments of uncinate fasciculus in first-episode drug-naïve adolescent depression

Kaili Liang1, Ruohan Feng1, Xuan Bu1, Suming Zhang1, Yingxue Gao1, Weijie Bao1, Lingxiao Cao1, Jing Liu1, Hailong Li1, Lianqing Zhang1, and Xiaoqi Huang1
1Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan University, Chengdu, China


We aimed to measure diffusion parameters along the uncinate fasciculus and examine the specific and focal alterations of the uncinate fasciculus in first-episode and drug-naïve patients with major depressive disorder in adolescents by using a tract-based quantitative technique. Notably, we found the opposite alterations of the diffusion metrics in the insular and frontal segments of left uncinate fasciculus in adolescents with depression. It will help us to better understand the neurobiological mechanisms of adolescent depression and optimize adolescent-specific treatments for depression.

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