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Abstract #3025

Unravel the Role of Primary Olfactory Cortices in Olfactory Processing via Optogenetic fMRI

Teng Ma1,2,3, Xunda Wang1,2, Linshan Xie1,2, Pit Shan Chong4, Peng Cao3, Pek-Lan Khong3, Lee Wei Lim4, Ed. X Wu1,2,4, and Alex T. L. Leong1,2
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, 3Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, 4School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

Synopsis

The anterior olfactory nucleus (AON) and the piriform cortex (Pir) are the two primary sensory cortices critical for olfaction. Although it is well documented that both cortices overlap significantly in their functions in olfactory processing, molecular and anatomical tracing studies have indicated otherwise. Consequently, our present understanding of the functions of AON and Pir in olfactory processing at the systems level remains incomplete. In this study, we employed optogenetic fMRI to interrogate the role of AON and Pir in processing olfactory inputs and beyond, and the associated long-range olfactory pathways and their spatiotemporal response properties.

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Keywords