Abstract #3026

Effects of Dobutamine on Neural Activity in Normal Subjects: A Exploratory Resting-State Functional MRI Study.

Yawen Liu¹, Pengling Ren², TingTing Zhang^1,2, Linkun Cai¹, Hao Wang², Hongxia Yin², Wei Zheng³, Yishi Wang⁴, Haijun Niu¹, Zhenghan Yang², Dehong Luo⁵, and Zhenchang Wang²

¹School of Biological Science and Medical Engineering, Beihang University, Beijing, China, ²Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China, ³National Space Science Center, Chinese Academy of Sciences, Beijing, China, ⁴Philips Heathcare, Beijing, China, ⁵National Cancer Center/Cancer Hospital and Shenzhen Hospital, Shenzhen, China

Synopsis

To explore the alternations in spontaneous brain activities in normal subjects after dobutamine infusion, the regional homogeneity (ReHo) method was used to analyze the interregional synchronized activity of all participants. The results showed that compared with normal resting state, significantly decreased ReHo was found after dobutamine infusion in bilateral frontal lobe, while increased in left temporal lobe and right parietal lobe, suggesting that dobutamine may have an effect on functional brain activity.

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