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Abstract #3026

Effects of Dobutamine on Neural Activity in Normal Subjects: A Exploratory Resting-State Functional MRI Study.

Yawen Liu1, Pengling Ren2, TingTing Zhang1,2, Linkun Cai1, Hao Wang2, Hongxia Yin2, Wei Zheng3, Yishi Wang4, Haijun Niu1, Zhenghan Yang2, Dehong Luo5, and Zhenchang Wang2
1School of Biological Science and Medical Engineering, Beihang University, Beijing, China, 2Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China, 3National Space Science Center, Chinese Academy of Sciences, Beijing, China, 4Philips Heathcare, Beijing, China, 5National Cancer Center/Cancer Hospital and Shenzhen Hospital, Shenzhen, China


To explore the alternations in spontaneous brain activities in normal subjects after dobutamine infusion, the regional homogeneity (ReHo) method was used to analyze the interregional synchronized activity of all participants. The results showed that compared with normal resting state, significantly decreased ReHo was found after dobutamine infusion in bilateral frontal lobe, while increased in left temporal lobe and right parietal lobe, suggesting that dobutamine may have an effect on functional brain activity.

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