Abstract #3049

Assessment of relationship between chemotherapy-induced brain structural alteration and neuropsychological scale revealed by GQI

Wei Chuang¹, Vincent Chin-Hung Chen^2,3, Yuan-Hsiung Tsai^2,4, and Jun-Cheng Weng^1,3,5

¹Department of Medical Imaging and Radiological Sciences, Graduate Institute of Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, ²School of Medicine, Chang Gung University, Taoyuan, Taiwan, ³Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁴Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁵Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan

Synopsis

Breast cancer is the most prevalent cancer among women, and most of them suffered from chemotherapy-related cognitive impairment (CRCI). In this study, we aimed to use generalized q-sampling imaging (GQI) to detect the relationship between GQI indices and mood symptoms caused by chemotherapy, post-traumatic stress disorder (PTSD), or post-traumatic growth (PTG). Using statistical multiple regression, we found the relationship change between GQI indices and depression, and a consistent relationship was obtained between GQI indices and anxiety with or without chemotherapy. The results indicated that neurotoxicity or traumatic stressors may affect brain structures.

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