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Abstract #3049

Assessment of relationship between chemotherapy-induced brain structural alteration and neuropsychological scale revealed by GQI

Wei Chuang1, Vincent Chin-Hung Chen2,3, Yuan-Hsiung Tsai2,4, and Jun-Cheng Weng1,3,5
1Department of Medical Imaging and Radiological Sciences, Graduate Institute of Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, 2School of Medicine, Chang Gung University, Taoyuan, Taiwan, 3Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, 4Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan, 5Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan


Breast cancer is the most prevalent cancer among women, and most of them suffered from chemotherapy-related cognitive impairment (CRCI). In this study, we aimed to use generalized q-sampling imaging (GQI) to detect the relationship between GQI indices and mood symptoms caused by chemotherapy, post-traumatic stress disorder (PTSD), or post-traumatic growth (PTG). Using statistical multiple regression, we found the relationship change between GQI indices and depression, and a consistent relationship was obtained between GQI indices and anxiety with or without chemotherapy. The results indicated that neurotoxicity or traumatic stressors may affect brain structures.

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