Fixel-Based Analysis of White Matter Degeneration in Patients with Huntington Disease
Chih-Chien Tsai1,2, Sher Li Oh3, Chiung-Mei Chen4, Yih-Ru Wu4, Maria Valdes Hernandez5,6, Jur-Shan Cheng7, Yao-Liang Chen8, Yi-Ming Wu8, Yu-Chun Lin8, and Jiun-Jie Wang1,2,9,10
1Department of Medical imaging and Radiological Science, Chang-Gung University, Taoyuan City, Taiwan, 2Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan, 3Nanyang Technological University, Singapore, Singapore, 4Department of Neurology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan, 5Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh, United Kingdom, 6Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 7Clinical Informatics and Medical Statistics Research Center, Chang-Gung University, Taoyuan City, Taiwan, 8Department of f Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan City, Taiwan, 9Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Taoyuan City, Taiwan, 10Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan
Microstructure damage in white matter might be linked to regional and global atrophy in Huntington Disease. Fixel-based analysis (FBA) has recently emerged as a useful fiber-specific tool for examining white matter structure, which could be an important contributor to the pathogenesis of Huntington’s disease. Therefore, we investigate the utility of FBA as a biomarker for disease progression. Our findings indicated the reductions in FBA occurs in major white matter tracts, which was closely co-localized with the regions of increased diffusivity in basal ganglia. FBA analysis is effective in studying white matter tractography and fiber changes in Huntington’s Disease.
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