Non-neuropsychiatric Childhood-onset Systemic Lupus Erythematosus: Changes in Brain Network Organization and White Matter Microstructure
Laleh Eskandarian1,2, Müşerref Kasap Cüceoğlu3, Selcan Demir3, Tuna Cak4, Ebru Cengel Kultur4, Yelda Bilginer3, Seza Ozen3, and Kader K Oguz2,5
1Neuroscience Department, Bilkent University, ANKARA, Turkey, 2National Magnetic Resonance Research Center (UMRAM), Bilkent University, ANKARA, Turkey, 3Faculty of Medicine, Department of Pediatrics, Division of Rheumatology, Hacettepe University, ANKARA, Turkey, 4Faculty of Medicine, Department of Pediatric Psychiatry, Hacettepe University, ANKARA, Turkey, 5Faculty of Medicine, Department of Radiology, Hacettepe University, ANKARA, Turkey
Central nervous system in childhood-onset SLE shows an increased risk of damage due to onset age, accumulating disease effect and other possible pathophysiologic mechanisms. Thus, an understanding of the timing and extent of changes occurring in the brains of these young patients with SLE is important for new therapeutic strategies. With this purpose, we investigated whether brain network and white matter microstructural changes occur in non-neuropsychiatric SLE patients with disease onset at childhood. TBSS and graph analysis of DTI data, showed significant alterations in white matter integrity and global and nodal connectivity, which revealed correlations with disease duration and severity.
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