Conversion map from quantitative parameter mapping to myelin water fraction
Shun Kitano1, Yuki Kanazawa2, Masafumi Harada2, Yo Taniguchi3, Yuki Matsumoto2, Hiroaki Hayashi4, Kosuke Ito3, Yoshitaka Bito3, and Akihiro Haga2
1Graduate of Health Science, Tokushima University, Tokushima, Japan, 2Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan, 3FUJIFILM Healthcare Corporation, Tokyo, Japan, 4College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
We determined MWF derived from QPM-relaxation parameters using quadratic polynomial approximation. Two types of myelin imaging were generated; MWF derived from multi-echo gradient-echo and R1·R2* map derived from QPM, which were standardized from twelve healthy volunteers to MNI. As a result, the relationship between MWF and R1·R2* values on the white matter region strongly correlated with a quadratic polynomial approximation (R2 = 0.991). Using acquired quadratic polynomial approximation, the R1·R2* map was converted to MWF. Our MWF map derived from QPM can dramatically improve image quality when compared to the general MWF.
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