Abstract #3052

Conversion map from quantitative parameter mapping to myelin water fraction

Shun Kitano¹, Yuki Kanazawa², Masafumi Harada², Yo Taniguchi³, Yuki Matsumoto², Hiroaki Hayashi⁴, Kosuke Ito³, Yoshitaka Bito³, and Akihiro Haga²

¹Graduate of Health Science, Tokushima University, Tokushima, Japan, ²Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan, ³FUJIFILM Healthcare Corporation, Tokyo, Japan, ⁴College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Synopsis

We determined MWF derived from QPM-relaxation parameters using quadratic polynomial approximation. Two types of myelin imaging were generated; MWF derived from multi-echo gradient-echo and R₁·R₂^* map derived from QPM, which were standardized from twelve healthy volunteers to MNI. As a result, the relationship between MWF and R₁·R₂^* values on the white matter region strongly correlated with a quadratic polynomial approximation (R²= 0.991). Using acquired quadratic polynomial approximation, the R₁·R₂^* map was converted to MWF. Our MWF map derived from QPM can dramatically improve image quality when compared to the general MWF.

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