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Abstract #3056

Anatomical changes and iron deposition of Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy on 7 Tesla MRI

Su Dongning1,2, Zhang Zhe2,3, Zhu Wanlin2,3, Sui Binbin2,3, Zhang Yingkui2,3, Bi Jingfeng2,3, Kong Qingle 4, Zhang Zhijin1,2, Gan Yawen1,2, Jin Jianing1,2, Wang Xuemei1,2, Wang Zhan1,2, Wang Yongjun 1,2,3, Wu Tao1,2, Jing Jing1,2,3, and Feng Tao1,2
1Department of Neurology, Beijing Tiantan Hospital,Captital Medical University, Beijing, China, 2China National Clinical Research Center for Neurological Diseases, Beijing, China, 3Tiantan Neuroimaging Center of Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 4MR Collaboration, Siemens Healthineers Ltd., Beijing, China


Ultra-high field MRI enables visualization of anatomical alterations and quantification of iron deposition in the subcortical nucleus. To investigate whether 7T MRI could provide the diagnostic opportunity for Parkinson-plus syndromes, we recruited PD, MSA-P, MSA-C and PSP patients who underwent multi-modal scans including 3D MPRAGE and 3D multi-echo T2*-weighted MRI. All six patients with MSA-C showed visible nigrosome-1. The distances from SN to RN were significantly shorter in PSP than PD. The R2* values in SN, RN and putamen were significantly higher in MSA-P than PD. Our pilot study provided first-of-its-kind evidence that 7T MRI could help diagnose Parkinson-plus syndromes.

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