Abstract #3057

Iron Spatial Distributions in Deep Gray Nuclei are Related to Motor Outcomes of Subthalamic Nuclei Deep Brain Stimulation for Parkinson's Disease

Weiwei Zhao¹, Xi Wu², Chunhui Yang², Luguang Chen³, Yiqing Qiu², Chao Ma³, Gaiying Li¹, Yang Song⁴, Yi Wang⁵, and Jianqi Li¹

¹East Chian Normal University, Shanghai, China, ²Department of Neurosurgery, Changhai Hospital, Shanghai, China, ³Department of Radiology, Changhai Hospital, Shanghai, China, ⁴MR Scientific Marketing, Siemens Healthineers, Shanghai, China, ⁵Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States

Synopsis

The objective of this study was to investigate the relationship between motor outcomes of subthalamic nuclei deep brain stimulation (STN-DBS) and spatial distribution of iron in the deep gray nuclei for patients with Parkinson's disease (PD). The first and second texture parameters were obtained from the preoperative QSM of 40 PD patients. Significant correlations were found between motor improvement after DBS and QSM texture parameters in substantia nigra (SN) and dentate nucleus (DN). Linear regression showed that second-order texture parameter angular second moment in SN (r = -0.449, p = 0.004) had the highest correlation with the STN-DBS motor outcomes.

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