Iron Spatial Distributions in Deep Gray Nuclei are Related to Motor Outcomes of Subthalamic Nuclei Deep Brain Stimulation for Parkinson's Disease
Weiwei Zhao1, Xi Wu2, Chunhui Yang2, Luguang Chen3, Yiqing Qiu2, Chao Ma3, Gaiying Li1, Yang Song4, Yi Wang5, and Jianqi Li1
1East Chian Normal University, Shanghai, China, 2Department of Neurosurgery, Changhai Hospital, Shanghai, China, 3Department of Radiology, Changhai Hospital, Shanghai, China, 4MR Scientific Marketing, Siemens Healthineers, Shanghai, China, 5Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States
The objective of this study was to investigate the relationship between motor outcomes of subthalamic nuclei deep brain stimulation (STN-DBS) and spatial distribution of iron in the deep gray nuclei for patients with Parkinson's disease (PD). The first and second texture parameters were obtained from the preoperative QSM of 40 PD patients. Significant correlations were found between motor improvement after DBS and QSM texture parameters in substantia nigra (SN) and dentate nucleus (DN). Linear regression showed that second-order texture parameter angular second moment in SN (r = -0.449, p = 0.004) had the highest correlation with the STN-DBS motor outcomes.
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