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Abstract #3058

Tract-specific association of myelin water fraction with cognitive decline and motor dysfunction in Parkinson’s disease

Septian Hartono1,2, Tiet Gan Ong3, Weiling Lee4, Zi Cheng Kuek4, Celeste Chen1, Kuan Jin Lee5, Jongho Lee6, Eng King Tan1,2, and Ling Ling Chan2,4
1National Neuroscience Institute, Singapore, Singapore, 2Duke-NUS Graduate Medical School, Singapore, Singapore, 3Nanyang Technological University, Singapore, Singapore, 4Singapore General Hospital, Singapore, Singapore, 5Institue of Bioengineering and Bioimaging, Singapore, Singapore, 6Seoul National University, Seoul, Korea, Republic of


We found associations between tract-specific myelin water fraction and cognitive decline, and motor dysfunction in patients with Parkinson’s disease (PD). Myelin water fractions (MWF) in the anterior corona radiata and posterior thalamic radiations were associated with cognitive decline in PD whilst those in the superior and posterior corona radiata, posterior limb of internal capsule and corticospinal tract were associated with moderate to severe motor dysfunction in PD. Our results suggest that MWF has potential utility as an objective imaging biomarker to monitor longitudinal changes in target WM tracts relevant to motor and cognitive dysfunction in PD neurodegeneration.

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