Abstract #3058

Tract-specific association of myelin water fraction with cognitive decline and motor dysfunction in Parkinson’s disease

Septian Hartono^1,2, Tiet Gan Ong³, Weiling Lee⁴, Zi Cheng Kuek⁴, Celeste Chen¹, Kuan Jin Lee⁵, Jongho Lee⁶, Eng King Tan^1,2, and Ling Ling Chan^2,4

¹National Neuroscience Institute, Singapore, Singapore, ²Duke-NUS Graduate Medical School, Singapore, Singapore, ³Nanyang Technological University, Singapore, Singapore, ⁴Singapore General Hospital, Singapore, Singapore, ⁵Institue of Bioengineering and Bioimaging, Singapore, Singapore, ⁶Seoul National University, Seoul, Korea, Republic of

Synopsis

We found associations between tract-specific myelin water fraction and cognitive decline, and motor dysfunction in patients with Parkinson’s disease (PD). Myelin water fractions (MWF) in the anterior corona radiata and posterior thalamic radiations were associated with cognitive decline in PD whilst those in the superior and posterior corona radiata, posterior limb of internal capsule and corticospinal tract were associated with moderate to severe motor dysfunction in PD. Our results suggest that MWF has potential utility as an objective imaging biomarker to monitor longitudinal changes in target WM tracts relevant to motor and cognitive dysfunction in PD neurodegeneration.

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