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Abstract #3059

Altered intrinsic functional connectivity across nine brain networks in early stages of idiopathic Parkinson’s disease

Yao-Chia Shih1,2,3, Pohchoo Seow1, Hartono Septian2,4, Welton Thomas2,4, Weiling Lee1, Aeden Zi Cheng Kuek1, Say Lee Chong1, Samuel Yong Ern Ng4, Nicole Shuang Yu Chia4, Eng-King Tan4, Louis CS Tan4, and Ling-Ling Chan1,2
1Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, 2Duke-NUS Medical School, Singapore, Singapore, 3Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan, 4Department of Neurology, National Neuroscience Institute – SGH Campus, Singapore, Singapore


Parkinson’s disease (PD) is a common neurodegenerative disease. Besides motor deficits, autonomic and cognitive dysfunctions might be caused by global abnormalities beyond the dopaminergic system. We performed resting-state fMRI to measure functional connectivity between the central autonomic network and eight other critical resting networks in both early PD and healthy control groups. Using general linear models, we identified functional impairments in the inter- and intra-network connections in relation to various brain functions. These findings could shed light on the neural mechanisms behind the complex clinical manifestations evident even in the early stages of PD.

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