Abstract #3060

Decreased LC MRI Contrast and Relationship with Orthostatic Hypotension in Multiple System Atrophy

Haiying Lv¹, Qing Li², and Yong Lu³

¹Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²MR Collaborations, Siemens Healthineers Ltd., Shanghai, China, ³Ruijin Hospital / Lu Wan Branch Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Synopsis

MRI imaging with Neuromelanin contrast has been thrived in recent years. We adopted this method again to explore the LC contrast differences in multiple system atrophy (MSA). Three methods for quantifying LC contrast were used, which all had the ability to reproduce the results that LC contrast decreases in MSA. We further did subgroup analyses of MSA with orthostatic hypotension (MSA-OH) and MSA without orthostatic hypotension (MSA-nonOH). Interestingly, although LC contrast of the two subgroups were not significantly different, adverse correlations between LC contrast and autonomic dysfunction severity were found in MSA-OH and MSA-nonOH subgroups.

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